Breast Cancer Markers in Blood Test: What They Mean and How Early Health Insights Support Better Care

December 16, 2025
Dr. Steven Lu
Chief Medical Officer | MBBS (hons) | DCH FRACGP
Breast Cancer Markers in Blood Test: What They Mean and How Early Health Insights Support Better Care

Understanding breast cancer markers in a blood test can feel overwhelming, especially if you are trying to be proactive about your health. While tumour marker tests cannot diagnose breast cancer or detect it early, they can provide useful information in specific clinical settings. They are mainly used after a diagnosis to help monitor cancer progression or treatment response.

This article explains how breast cancer markers work, what they can and cannot tell you, and how earlier engagement with health information may support better outcomes.

What Are Breast Cancer Markers in a Blood Test?

Breast cancer biomarkers are measurable substances - often proteins - found in the blood. Some of these markers may rise when breast cancer is present, particularly in more advanced stages.

However, it’s important to understand:

  1. Breast cancer markers cannot diagnose breast cancer
  2. They do not detect early breast cancer
  3. They are not used for screening
  4. They require clinical interpretation by a healthcare professional

Even so, they can support decision-making when used appropriately, particularly in ongoing care.

1. Key Breast Cancer Markers in Blood Tests

Here are the main tumour markers used in breast cancer monitoring and what they tell clinicians.

1.1 CA 15-3 (Cancer Antigen 15-3)

A commonly measured marker associated with some forms of breast cancer.

Most useful for:

  • Monitoring metastatic breast cancer
  • Tracking changes during treatment

Limitations:

  • Often normal in early-stage breast cancer
  • Not suitable for general screening

1.2 CA 27-29

Very similar to CA 15-3 and used in comparable situations.

Useful for:

  • Observing trends in known breast cancer

Limitations:

  • Can rise due to non-cancerous causes
  • Not a diagnostic test

1.3 CEA (Carcinoembryonic Antigen)

A non-specific tumour marker.

Useful for:

  • Monitoring advanced or metastatic cancer under specialist care

Limitations:

  • Not breast cancer–specific
  • Cannot detect cancer early

1.4 Emerging Markers (e.g., ctDNA)

Used selectively in specialist oncology settings.

Limitations:

  • Not used for screening or diagnosing breast cancer

Quick Comparison Table: Breast Cancer Markers in Blood Tests

Biomarker Best For Not For Notes
CA 15-3 Monitoring metastatic breast cancer Screening or early detection Trends over time are more useful than a single result.
CA 27-29 Long-term monitoring of known breast cancer Diagnosing or ruling out cancer Very similar to CA 15-3 and used in similar contexts.
CEA Monitoring some advanced or metastatic cancers Detecting early breast cancer Non-specific marker; can be raised in smokers and other conditions.
HER2 (blood) Supporting treatment decisions in selected cases General breast cancer screening Emerging test; blood-based use is not yet routine.
ESR1 mutation Guiding therapy in specialist oncology settings Screening or early detection Genomic marker used mainly for treatment planning.

2. How Tumour Markers Support Health Monitoring

Breast cancer markers cannot predict a person’s risk or detect cancer early. However, accessible testing can still play a helpful role in proactive health engagement.

This highlights the value of early engagement, not early diagnosis.

3. Preparing for Breast Cancer Marker Blood Testing

Even when the test is simple, knowing what to expect can help you get the most accurate results.

Know why the test is being ordered

Tumour marker tests are usually arranged for people who:

  • have been diagnosed with breast cancer
  • are receiving treatment
  • are being monitored long-term
  • have a clinical reason to investigate further

Some individuals also access testing independently for personal health insights.

Fasting is usually not required

Confirm with your test provider.

Avoid short-term factors that may affect results

Where possible, avoid:

  • heavy activity
  • alcohol
  • smoking

Share relevant medical updates with your doctor

Temporary conditions such as infections or inflammation can influence tumour marker levels.

Follow-up is essential

A single abnormal reading is not a diagnosis. Clinicians may request repeat tests or imaging.

4. How Everlab Supports Earlier Engagement With Your Health

Everlab gives Australians convenient access to selected blood tests, including tumour marker tests used in breast cancer monitoring.

While these tests cannot detect cancer early, they can help people:

  • stay engaged with their health
  • identify when results should be discussed with a clinician
  • take action sooner if additional assessment is recommended
  • maintain a clear record of their health information over time

Everlab supports proactive health management by making information available earlier — always with the guidance of a qualified healthcare professional.

Conclusion

Breast cancer markers in a blood test are most useful for monitoring known breast cancer rather than detecting it early or diagnosing it. When used in the correct clinical context, they can help inform treatment decisions and highlight when further tests may be needed.

Everlab supports people who want accessible health information and encourages timely conversations with healthcare providers. While tumour markers cannot detect early breast cancer, early engagement with your health data can contribute to more timely care when results are reviewed by a qualified clinician.

Frequently Asked Questions

1. Are breast cancer markers in a blood test used for screening?

No. They cannot detect early breast cancer and do not replace imaging.

2. Can lifestyle changes reduce breast cancer risk?

Yes. Evidence supports maintaining a healthy weight, staying active, limiting alcohol, and avoiding smoking.

3. Do I need a referral for tumour marker testing?

Some tests may be accessed through Everlab without a referral, but medical interpretation is essential.

4. What does it mean if my tumour marker levels are high?

Elevated levels do not necessarily mean cancer is present. Clinicians may repeat testing, review medical history, or recommend imaging.

References:

Dr. Steven Lu
Chief Medical Officer | MBBS (hons) | DCH FRACGP

Steven is a specialist general practitioner, preventative health consultant, medical educator, healthcare entrepreneur and co-founder of Everlab. With 15+ years of clinical experience, and driven by his passion for preventive care outcomes, Steven is dedicated to personalised and innovative approaches to enhance well-being, extend human lifespan, and improve healthspan.

Understanding breast cancer markers in a blood test can feel overwhelming, especially if you are trying to be proactive about your health. While tumour marker tests cannot diagnose breast cancer or detect it early, they can provide useful information in specific clinical settings. They are mainly used after a diagnosis to help monitor cancer progression or treatment response.

This article explains how breast cancer markers work, what they can and cannot tell you, and how earlier engagement with health information may support better outcomes.

What Are Breast Cancer Markers in a Blood Test?

Breast cancer biomarkers are measurable substances - often proteins - found in the blood. Some of these markers may rise when breast cancer is present, particularly in more advanced stages.

However, it’s important to understand:

  1. Breast cancer markers cannot diagnose breast cancer
  2. They do not detect early breast cancer
  3. They are not used for screening
  4. They require clinical interpretation by a healthcare professional

Even so, they can support decision-making when used appropriately, particularly in ongoing care.

1. Key Breast Cancer Markers in Blood Tests

Here are the main tumour markers used in breast cancer monitoring and what they tell clinicians.

1.1 CA 15-3 (Cancer Antigen 15-3)

A commonly measured marker associated with some forms of breast cancer.

Most useful for:

  • Monitoring metastatic breast cancer
  • Tracking changes during treatment

Limitations:

  • Often normal in early-stage breast cancer
  • Not suitable for general screening

1.2 CA 27-29

Very similar to CA 15-3 and used in comparable situations.

Useful for:

  • Observing trends in known breast cancer

Limitations:

  • Can rise due to non-cancerous causes
  • Not a diagnostic test

1.3 CEA (Carcinoembryonic Antigen)

A non-specific tumour marker.

Useful for:

  • Monitoring advanced or metastatic cancer under specialist care

Limitations:

  • Not breast cancer–specific
  • Cannot detect cancer early

1.4 Emerging Markers (e.g., ctDNA)

Used selectively in specialist oncology settings.

Limitations:

  • Not used for screening or diagnosing breast cancer

Quick Comparison Table: Breast Cancer Markers in Blood Tests

Biomarker Best For Not For Notes
CA 15-3 Monitoring metastatic breast cancer Screening or early detection Trends over time are more useful than a single result.
CA 27-29 Long-term monitoring of known breast cancer Diagnosing or ruling out cancer Very similar to CA 15-3 and used in similar contexts.
CEA Monitoring some advanced or metastatic cancers Detecting early breast cancer Non-specific marker; can be raised in smokers and other conditions.
HER2 (blood) Supporting treatment decisions in selected cases General breast cancer screening Emerging test; blood-based use is not yet routine.
ESR1 mutation Guiding therapy in specialist oncology settings Screening or early detection Genomic marker used mainly for treatment planning.

2. How Tumour Markers Support Health Monitoring

Breast cancer markers cannot predict a person’s risk or detect cancer early. However, accessible testing can still play a helpful role in proactive health engagement.

This highlights the value of early engagement, not early diagnosis.

3. Preparing for Breast Cancer Marker Blood Testing

Even when the test is simple, knowing what to expect can help you get the most accurate results.

Know why the test is being ordered

Tumour marker tests are usually arranged for people who:

  • have been diagnosed with breast cancer
  • are receiving treatment
  • are being monitored long-term
  • have a clinical reason to investigate further

Some individuals also access testing independently for personal health insights.

Fasting is usually not required

Confirm with your test provider.

Avoid short-term factors that may affect results

Where possible, avoid:

  • heavy activity
  • alcohol
  • smoking

Share relevant medical updates with your doctor

Temporary conditions such as infections or inflammation can influence tumour marker levels.

Follow-up is essential

A single abnormal reading is not a diagnosis. Clinicians may request repeat tests or imaging.

4. How Everlab Supports Earlier Engagement With Your Health

Everlab gives Australians convenient access to selected blood tests, including tumour marker tests used in breast cancer monitoring.

While these tests cannot detect cancer early, they can help people:

  • stay engaged with their health
  • identify when results should be discussed with a clinician
  • take action sooner if additional assessment is recommended
  • maintain a clear record of their health information over time

Everlab supports proactive health management by making information available earlier — always with the guidance of a qualified healthcare professional.

Conclusion

Breast cancer markers in a blood test are most useful for monitoring known breast cancer rather than detecting it early or diagnosing it. When used in the correct clinical context, they can help inform treatment decisions and highlight when further tests may be needed.

Everlab supports people who want accessible health information and encourages timely conversations with healthcare providers. While tumour markers cannot detect early breast cancer, early engagement with your health data can contribute to more timely care when results are reviewed by a qualified clinician.

Frequently Asked Questions

1. Are breast cancer markers in a blood test used for screening?

No. They cannot detect early breast cancer and do not replace imaging.

2. Can lifestyle changes reduce breast cancer risk?

Yes. Evidence supports maintaining a healthy weight, staying active, limiting alcohol, and avoiding smoking.

3. Do I need a referral for tumour marker testing?

Some tests may be accessed through Everlab without a referral, but medical interpretation is essential.

4. What does it mean if my tumour marker levels are high?

Elevated levels do not necessarily mean cancer is present. Clinicians may repeat testing, review medical history, or recommend imaging.

References:

Dr. Steven Lu
Chief Medical Officer | MBBS (hons) | DCH FRACGP

Steven is a specialist general practitioner, preventative health consultant, medical educator, healthcare entrepreneur and co-founder of Everlab. With 15+ years of clinical experience, and driven by his passion for preventive care outcomes, Steven is dedicated to personalised and innovative approaches to enhance well-being, extend human lifespan, and improve healthspan.

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Breast Cancer Markers in Blood Test: What They Mean and How Early Health Insights Support Better Care

Learn what breast cancer markers in blood tests mean, their limits, and how Everlab supports early engagement, medical review and care

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